Corticosteroids: Barbiturates appear to enhance the metabolism of exogenous corticosteroids probably through the induction of hepatic microsomal enzymes. Patients stabilized on corticosteroid therapy may require dosage adjustments if barbiturates are added to or withdrawn from their dosage regimen.
Studies in young animals and children have shown that frequent or long-term use of anesthesia drugs or drugs used for sleep hinein children younger than 3 years of age may lead to long-term brain problems.
Elderly patients may react to barbiturates with marked excitement, depression, and confusion. In some persons, barbiturates repeatedly produce excitement rather than depression. Dosage should be reduced in the elderly because these patients may be more sensitive to barbiturates.
Because such patients may be less aware of certain of the milder adverse effects of barbiturates, the incidence of these reactions may be somewhat higher rein fully ambulatory patients.
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The use of a Luer-Triebfahrzeug® syringe is recommended to prevent accidental exposure due to needle/syringe separation.
Use with caution rein pregnant women and children below 3 years of age. Pentobarbital can affect fetal and young children’s brain development.
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
Published animal studies demonstrate that the administration of anesthetic and sedation drugs that Notizblock NMDA receptors and/or potentiate GABA activity increase neuronal apoptosis rein the developing brain and result in long-term cognitive deficits when used for longer than 3 hours. The clinical significance of these findings is not clear.
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Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine. What should I watch for while using this medication?
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
Drug interactions: Most reports of clinically significant drug interactions occurring with the barbiturates have involved phenobarbital.